ZNF436

Across TCGA pan-cancer cohorts, ZNF436 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ZNF436’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ZNF436 RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF436 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, LIHC, and BLCA are the cancer types where ZNF436 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF436 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.018	.003	8	view →
LIHC	Female	II,III,IV	+0.923	<.001	8	view →
BLCA	Male	All	+1.210	.001	7	view →
KICH	Female	All	−1.032	<.001	7	view →
KIRC	All	All	+0.347	<.001	7	view →
LUSC	Female	All	+1.284	<.001	6	view →
HNSC	Female	All	+0.697	.005	6	view →
CHOL	Male	All	+1.538	<.001	5	view →
LUAD	Male	All	+0.520	<.001	5	view →
BRCA	All	All	−0.239	.001	4	view →
COAD	Female	All	−0.451	.024	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ZNF436–THCA

Open the THCA breakdown →