ZNF436

Across TCGA patient cohorts, ZNF436 mutation is significantly associated with the RNA expression of many other genes, with 2,836 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF436-associated genes across cancer lineages are HMGB1P48, PRIMPOL, and MIR3170. Each is linked with ZNF436 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF436-to-partner and partner-to-ZNF436 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMGB1P48 grouped by ZNF436-low versus ZNF436-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF436→partner) and Y-score (partner→ZNF436) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	HMGB1P48 →	+0.145	+4.245	.002	.008	3	3
UCEC	PRIMPOL →	+0.431	+2.758	<.001	<.001	3	3
LIHC	MIR3170 →	+0.388	+4.293	<.001	.009	3	3
UCEC	TIFA →	+0.338	+1.443	.008	.003	3	3
UCEC	EIF3JP1 →	+0.173	+1.864	<.001	<.001	3	3
BRCA	RBM22P6 →	+0.061	+5.317	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,836 associations by consensus.

HMGB1P48 by ZNF436 expression — HNSC

Explore this box plot interactively →