ZNF436

Across TCGA patient cohorts, ZNF436 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF436-associated genes across cancer lineages are C-Raf, eEF2, and A-Raf_pS299. Each is linked with ZNF436 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF436-to-partner and partner-to-ZNF436 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by ZNF436-low versus ZNF436-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF436→partner) and Y-score (partner→ZNF436) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	C-Raf →	+0.331	+3.321	<.001	.010	3	2
UCEC	eEF2 →	+0.250	+2.459	.036	.018	3	2
UCEC	A-Raf_pS299 →	-0.145	-2.502	<.001	.001	3	2
UCEC	FOXO3a_pS318_S321 →	-0.114	-1.838	.006	.007	3	2
UCEC	JNK2 →	+0.226	+1.512	<.001	.017	3	2
UCEC	MEK1 →	+0.348	+1.584	.004	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

C-Raf by ZNF436 expression — BLCA

Explore this box plot interactively →