ZNF436-AS1

Across TCGA pan-cancer cohorts, ZNF436-AS1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated ZNF436-AS1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZNF436-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated ZNF436-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BLCA show a favorable association.

HNSC, KIRC, and BLCA are the cancer types where ZNF436-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.749	0.621	<.001	102	view →
KIRC	DFS	Median	All	0.506	0.718	<.001	96	view →
BLCA	OS	Tertile	All	0.621	0.347	<.001	74	view →
PAAD	OS	Median	All	0.579	0.395	.001	53	view →
SKCM	OS	Tertile	III,IV	0.546	0.265	.001	48	view →
LGG	DFS	Median	All	0.622	0.841	<.001	47	view →
ACC	DFS	Tertile	All	0.432	0.755	.007	27	view →
UCS	DFS	Median	IV	0.952	0.367	.001	24	view →
MESO	DFS	Tertile	II,III,IV	0.289	0.814	.006	24	view →
BRCA	OS	Quartile	III,IV	0.915	0.709	<.001	20	view →
PRAD	DFS	Median	All	0.840	0.927	.001	20	view →
ESCA	DFS	Median	IV	0.205	0.634	.006	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

ZNF436-AS1–HNSC (DFS)

Open the HNSC breakdown →