ZNF436-AS1

Across TCGA pan-cancer cohorts, ZNF436-AS1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of ZNF436-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ZNF436-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZNF436-AS1 is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

KIRC, LIHC, and KICH are the cancer types where ZNF436-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF436-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	+0.761	<.001	12	view →
LIHC	Male	All	+0.421	<.001	8	view →
KICH	Female	All	−0.950	<.001	7	view →
BRCA	All	All	−0.759	<.001	6	view →
LUSC	All	II,III,IV	+0.691	<.001	6	view →
LUAD	All	All	+0.400	<.001	6	view →
COAD	Male	II,III,IV	+0.308	.004	6	view →
BLCA	All	All	+0.743	.002	5	view →
CHOL	All	All	+0.912	<.001	3	view →
ESCA	All	II,III,IV	+0.395	.033	2	view →
UCEC	All	All	−0.333	.049	2	view →
PRAD	All	All	−0.178	.039	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

ZNF436-AS1–KIRC

Open the KIRC breakdown →