Across TCGA cell cohorts, ZNF431 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF431-associated genes across cancer lineages are C12orf40, IL25, and TBC1D21. Each is linked with ZNF431 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF431-to-partner and partner-to-ZNF431 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF431→partner) and Y-score (partner→ZNF431) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	C12orf40 →	+0.011	+4.029	<.001	.009	3	1
LUNG_NSCLC_LUAD	IL25 →	+0.016	+5.662	<.001	.002	3	1
LARGE_INTESTINE	TBC1D21 →	+0.020	+6.022	<.001	.001	3	1
LARGE_INTESTINE	OR10W1 →	+0.022	+4.977	<.001	.007	3	1
LARGE_INTESTINE	CCER1 →	+0.012	+4.977	<.001	.007	3	1
LARGE_INTESTINE	PYDC2 →	+0.145	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

ZNF431 survival (RNA) · tumor vs normal (RNA) · all ZNF431 data types