Across TCGA pan-cancer cohorts, ZNF431 RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated ZNF431 data layer compared with 5 for mutation status.
The strongest signal is observed in uveal melanoma (UVM), where higher ZNF431 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZNF431 expression acts as an unfavorable survival marker, although some lineages such as LAML and SCLC show a favorable association.
UVM, KIRC, and LAML are the cancer types where ZNF431 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.