Across TCGA cell cohorts, ZNF431 mutation is significantly associated with the mutation status of many other genes, with 2,895 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF431-associated genes across cancer lineages are ZNF224, IPO7, and CRACD. Each is linked with ZNF431 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF431-to-partner and partner-to-ZNF431 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF431→partner) and Y-score (partner→ZNF431) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ZNF224 →	+5.014	+5.584	.003	.003	1	4
SKIN	IPO7 →	+4.239	+5.053	.007	.007	1	4
BLOOD_Leukemia	CRACD →	+2.894	+4.432	.005	.005	1	4
OVARY	ERCC6 →	+3.632	+3.930	.003	.003	1	4
BLOOD_Lymphoma	TMEM63C →	+4.429	+5.247	.005	.005	1	4
BLOOD_Leukemia	MSH6 →	+3.020	+4.545	.004	.004	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,895 associations by consensus.

Exploration

ZNF431 survival (RNA) · tumor vs normal (RNA) · all ZNF431 data types