ZNF426

Across TCGA patient cohorts, ZNF426 mutation is significantly associated with the RNA expression of many other genes, with 1,630 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF426-associated genes across cancer lineages are RPL23AP22, TRAJ47, and IGHD5-12. Each is linked with ZNF426 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF426-to-partner and partner-to-ZNF426 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL23AP22 grouped by ZNF426-low versus ZNF426-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF426→partner) and Y-score (partner→ZNF426) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RPL23AP22 →	+0.141	+5.337	<.001	.006	3	2
SKCM	TRAJ47 →	+0.396	+3.578	.001	.007	3	2
SKCM	IGHD5-12 →	+1.082	+3.796	.002	.002	3	2
COAD	RNA5SP136 →	+0.417	+7.741	<.001	.009	3	2
UCEC	SLC25A5P4 →	+0.082	+1.983	.008	.001	3	2
UCEC	RNA5SP421 →	+0.434	+1.773	.006	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,630 associations by consensus.

RPL23AP22 by ZNF426 expression — LUSC

Explore this box plot interactively →