ZNF426

Across TCGA pan-cancer cohorts, ZNF426 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ZNF426’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ZNF426 RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF426 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, KIRC, and LIHC are the cancer types where ZNF426 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF426 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−0.462	<.001	7	view →
KIRC	All	II,III,IV	−0.385	.002	7	view →
LIHC	Female	All	+0.848	<.001	6	view →
BRCA	All	All	−0.248	.002	6	view →
LUAD	Female	II,III,IV	−0.521	.007	4	view →
CHOL	All	All	+1.835	<.001	2	view →
READ	All	III,IV	+0.545	.010	2	view →
HNSC	All	II,III,IV	−0.472	.013	2	view →
UCEC	All	All	−0.446	.026	2	view →
PAAD	Female	All	−0.415	.001	2	view →
BLCA	Female	IV	−0.299	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ZNF426–THCA

Open the THCA breakdown →