ZNF426

Across TCGA patient cohorts, ZNF426 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF426-associated genes across cancer lineages are p62 Lck ligand, eIF4E, and ERK2. Each is linked with ZNF426 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF426-to-partner and partner-to-ZNF426 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by ZNF426-low versus ZNF426-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF426→partner) and Y-score (partner→ZNF426) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.282	+2.469	.021	.010	3	2
UCEC	eIF4E →	+0.180	+3.183	.023	.009	3	1
UCEC	ERK2 →	+0.158	+1.765	.028	.014	3	1
UCEC	JNK_pT183_Y185 →	-0.128	-1.401	.043	.046	3	1
UCEC	JNK2 →	+0.228	+2.125	.002	.010	3	1
UCEC	MEK1 →	+0.284	+2.115	.038	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

p62 Lck ligand by ZNF426 expression — UCEC

Explore this box plot interactively →