ZNF426-DT

Across TCGA pan-cancer cohorts, ZNF426-DT RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated ZNF426-DT data layer.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher ZNF426-DT RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated ZNF426-DT expression acts as an unfavorable survival marker, although some lineages such as BLCA and UVM show a favorable association.

BLCA, UVM, and OV are the cancer types where ZNF426-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Median	All	0.574	0.441	.001	77	view →
UVM	DFS	Tertile	All	0.990	0.600	<.001	59	view →
OV	OS	Tertile	All	0.755	0.628	.006	48	view →
KIRP	OS	Tertile	All	0.816	0.575	.007	35	view →
UCEC	DFS	Median	All	0.730	0.553	.002	34	view →
LGG	DFS	Quartile	All	0.892	0.690	.001	26	view →
ACC	OS	Quartile	IV	0.887	0.237	.006	26	view →
UCS	DFS	Quartile	II,III,IV	0.510	0.121	.016	18	view →
MESO	OS	Tertile	II,III,IV	0.515	0.267	.004	15	view →
STAD	DFS	Tertile	IV	0.625	0.245	.004	12	view →
LIHC	OS	Quartile	III,IV	0.810	0.333	<.001	11	view →
READ	OS	Quartile	III,IV	1.000	0.764	.017	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

ZNF426-DT–BLCA (DFS)

Open the BLCA breakdown →