ZNF426-DT

Across TCGA pan-cancer cohorts, ZNF426-DT RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ZNF426-DT’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ZNF426-DT RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF426-DT is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and LIHC are the cancer types where ZNF426-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF426-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.284	<.001	11	view →
KICH	Male	III,IV	−2.282	<.001	10	view →
LIHC	All	All	+0.558	<.001	7	view →
THCA	Male	All	−0.674	<.001	6	view →
BRCA	All	II,III,IV	−0.658	<.001	6	view →
KIRP	All	All	−0.808	<.001	5	view →
LUAD	All	All	−0.369	<.001	5	view →
COAD	Female	II,III,IV	+0.470	.011	4	view →
BLCA	Male	IV	−1.387	.002	2	view →
CHOL	All	All	+1.152	.003	2	view →
LUSC	All	III,IV	−0.833	.004	2	view →
READ	All	III,IV	−0.585	.012	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ZNF426-DT–KIRC

Open the KIRC breakdown →