ZNF423

Across TCGA patient cohorts, ZNF423 mutation is significantly associated with the RNA expression of many other genes, with 4,962 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF423-associated genes across cancer lineages are GNPNAT1, CHAC2, and GINS3. Each is linked with ZNF423 in more than 4 cancer types. Because this analysis shows association rather than direction, both ZNF423-to-partner and partner-to-ZNF423 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GNPNAT1 grouped by ZNF423-low versus ZNF423-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF423→partner) and Y-score (partner→ZNF423) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	GNPNAT1 →	+0.605	+3.584	<.001	.002	3	5
COAD	CHAC2 →	+0.591	+3.906	<.001	<.001	3	5
UCEC	GINS3 →	+0.443	+1.462	<.001	<.001	3	4
STAD	SYNJ2BP →	+0.370	+2.148	.006	.008	3	4
COAD	DCST1-AS1 →	+0.474	+2.200	<.001	.001	3	4
UCEC	PTMAP9 →	+0.567	+1.484	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,962 associations by consensus.

GNPNAT1 by ZNF423 expression — STAD

Explore this box plot interactively →