ZNF423

Across TCGA pan-cancer cohorts, ZNF423 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of ZNF423’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where ZNF423 RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF423 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

LUAD, LUSC, and THCA are the cancer types where ZNF423 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF423 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−1.255	<.001	11	view →
LUSC	All	II,III,IV	−1.094	<.001	8	view →
THCA	All	II,III,IV	−0.596	<.001	8	view →
COAD	Male	All	−0.732	.001	7	view →
KICH	All	All	−0.619	<.001	7	view →
LIHC	Female	All	+0.480	<.001	7	view →
BLCA	Male	IV	−1.677	.003	6	view →
BRCA	Female	II,III,IV	−0.965	<.001	6	view →
UCEC	All	All	−1.234	.004	2	view →
PRAD	All	All	−0.625	<.001	2	view →
KIRP	Male	All	−0.602	<.001	2	view →
CHOL	All	All	+0.573	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

ZNF423–LUAD

Open the LUAD breakdown →