ZNF423

Across TCGA patient cohorts, ZNF423 mutation is significantly associated with the total protein of many other genes, with 91 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF423-associated genes across cancer lineages are ATM, INPP4B, and GAPDH. Each is linked with ZNF423 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF423-to-partner and partner-to-ZNF423 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ZNF423-low versus ZNF423-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF423→partner) and Y-score (partner→ZNF423) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.408	-2.379	<.001	<.001	3	4
SKCM	INPP4B →	-0.180	-2.375	.007	<.001	3	4
UCEC	GAPDH →	+0.365	+1.584	.011	.032	3	3
UCEC	PCNA →	+0.259	+1.999	<.001	<.001	3	3
STAD	Caspase-7-cleavedD198 →	+0.903	+2.321	<.001	.030	3	3
UCEC	Cyclin-B1 →	+0.664	+2.938	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 91 associations by consensus.

ATM by ZNF423 expression — UCEC

Explore this box plot interactively →