ZNF423

Across TCGA cell cohorts, ZNF423 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,875 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF423-associated GO terms across cancer lineages are Regulation of nucleotide-excision repair, Establishment of skin barrier, and Nucleoside triphosphate metabolic process. Each is linked with ZNF423 in more than 9 cancer types. Because this analysis shows association rather than direction, both ZNF423-to-partner and partner-to-ZNF423 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of nucleotide-excision repair grouped by ZNF423-low versus ZNF423-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF423→partner) and Y-score (partner→ZNF423) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of nucleotide-excision repair →	+0.124	+1.670	<.001	.001	3	10
OVARY	Establishment of skin barrier →	-0.202	-1.338	.001	.004	3	7
LUNG_SCLC	Nucleoside triphosphate metabolic process →	+0.064	+1.322	.002	.002	3	7
OVARY	Regulation of coagulation →	-0.182	-1.052	<.001	.009	3	7
SOFT_TISSUE	ATP synthesis coupled electron transport →	+0.051	+1.308	.009	<.001	3	7
SOFT_TISSUE	Mitochondrial ATP synthesis coupled electron transport →	+0.051	+1.308	.009	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,875 associations by consensus.

Regulation of nucleotide-excision repair by ZNF423 expression — BONE

Explore this box plot interactively →