ZNF423

Across TCGA cell cohorts, ZNF423 mutation is significantly associated with the RNA expression of many other genes, with 404 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF423-associated genes across cancer lineages are SLC35G3, SCGB2A2, and ARL5B. Each is linked with ZNF423 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF423-to-partner and partner-to-ZNF423 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC35G3 grouped by ZNF423-low versus ZNF423-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF423→partner) and Y-score (partner→ZNF423) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	SLC35G3 →	+0.005	+4.087	<.001	.009	3	3
SOFT_TISSUE	SCGB2A2 →	+0.353	+3.142	.008	.008	3	2
BREAST	ARL5B →	+0.663	+3.152	.008	.009	3	2
BLOOD_Leukemia	TNFSF8 →	+1.793	+3.894	<.001	.001	3	2
BLOOD_Leukemia	LGI1 →	+0.049	+3.802	<.001	.001	3	2
BLOOD_Leukemia	CCR8 →	+1.484	+3.608	.004	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 404 associations by consensus.

SLC35G3 by ZNF423 expression — URINARY_TRACT

Explore this box plot interactively →