ZNF420

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, ZNF420 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF420-associated genes across cancer lineages are TFRC, EGFR_pY1068, and mTOR_pS2448. Each is linked with ZNF420 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF420-to-partner and partner-to-ZNF420 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF420→partner) and Y-score (partner→ZNF420) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECTFRC →+0.365+2.584.029.01033
UCECEGFR_pY1068 →-0.204-1.584.009.00532
UCECmTOR_pS2448 →-0.094-1.893.044.01432
UCECp27_pT198 →+0.096+1.584.004.00532
UCECp62 Lck ligand →+0.423+2.115<.001<.00132
UCECCaspase-7-cleavedD198 →+0.424+1.300.023.03432
Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Exploration