ZNF417

Across TCGA patient cohorts, ZNF417 mutation is significantly associated with the RNA expression of many other genes, with 1,677 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF417-associated genes across cancer lineages are FAM177A1, PBX3, and NCAPH2. Each is linked with ZNF417 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF417-to-partner and partner-to-ZNF417 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM177A1 grouped by ZNF417-low versus ZNF417-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF417→partner) and Y-score (partner→ZNF417) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FAM177A1 →	+0.339	+2.254	.002	.005	3	2
UCEC	PBX3 →	+0.573	+2.137	.004	.001	3	2
UCEC	NCAPH2 →	+0.460	+3.000	<.001	<.001	3	2
SKCM	SETD3 →	+0.574	+3.195	.002	.009	3	2
UCEC	NF2 →	+0.546	+2.148	<.001	<.001	3	2
UCEC	IGHD6-6 →	+0.398	+2.283	.003	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,677 associations by consensus.

FAM177A1 by ZNF417 expression — UCEC

Explore this box plot interactively →