ZNF417

Across TCGA patient cohorts, ZNF417 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF417-associated genes across cancer lineages are STAT3_pY705, CD49b, and FoxM1. Each is linked with ZNF417 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF417-to-partner and partner-to-ZNF417 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by ZNF417-low versus ZNF417-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF417→partner) and Y-score (partner→ZNF417) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.407	-1.847	<.001	.008	3	2
SKCM	CD49b →	+0.364	+2.824	.010	.036	2	2
UCEC	FoxM1 →	+0.244	+2.247	.010	.001	3	1
UCEC	GSK-3_pS9 →	-0.301	-1.874	.042	.049	3	1
UCEC	INPP4B →	-0.262	-2.000	.027	.029	3	1
UCEC	JNK2 →	+0.249	+1.502	<.001	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

STAT3_pY705 by ZNF417 expression — UCEC

Explore this box plot interactively →