ZNF415

Across TCGA patient cohorts, ZNF415 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF415-associated genes across cancer lineages are Shc_pY317, EGFR_pY1068, and eIF4E. Each is linked with ZNF415 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF415-to-partner and partner-to-ZNF415 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by ZNF415-low versus ZNF415-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF415→partner) and Y-score (partner→ZNF415) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.144	-2.000	.007	.029	3	3
UCEC	EGFR_pY1068 →	-0.247	-2.000	.005	.003	3	2
UCEC	eIF4E →	+0.158	+2.000	.034	.003	3	2
UCEC	MEK1 →	+0.394	+2.807	.002	.002	3	2
UCEC	mTOR_pS2448 →	-0.166	-3.571	.001	.002	3	2
UCEC	PDCD4 →	-0.575	-1.662	<.001	.011	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Shc_pY317 by ZNF415 expression — UCEC

Explore this box plot interactively →