ZNF414

Across TCGA pan-cancer cohorts, ZNF414 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ZNF414 data layer compared with 24 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher ZNF414 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZNF414 expression acts as an unfavorable survival marker.

SCLC, BLCA, and UCEC are the cancer types where ZNF414 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	DFS	Median	II,III,IV	0.110	0.615	<.001	30	view →
BLCA	DFS	Median	All	0.122	0.626	.001	24	view →
UCEC	OS	Median	III,IV	0.061	0.588	.018	18	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ZNF414–SCLC (DFS)

Open the SCLC breakdown →