ZNF414

Across TCGA pan-cancer cohorts, ZNF414 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of ZNF414’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where ZNF414 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZNF414 is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

LIHC, COAD, and KIRC are the cancer types where ZNF414 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF414 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+1.200	<.001	9	view →
COAD	Female	All	+0.754	<.001	8	view →
KIRC	Female	All	+0.431	<.001	8	view →
THCA	Male	II,III,IV	−0.423	.001	7	view →
KIRP	All	II,III,IV	+0.456	.005	6	view →
LUAD	All	All	−0.265	.001	5	view →
CHOL	All	All	+1.517	<.001	3	view →
HNSC	Male	III,IV	+0.419	.011	3	view →
ESCA	All	All	+0.480	.017	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

ZNF414–LIHC

Open the LIHC breakdown →