ZNF414

Across TCGA pan-cancer cohorts, ZNF414 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ZNF414 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher ZNF414 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ZNF414 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

LUAD, PDAC, and HNSC are the cancer types where ZNF414 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	All	0.869	0.421	.015	15	view →
PDAC	DFS	Quartile	III,IV	0.257	0.932	.004	15	view →
HNSC	DFS	Median	IV	0.328	0.889	.014	8	view →
LSCC	OS	Quartile	II,III,IV	1.000	0.726	.018	7	view →
CCRCC	OS	Tertile	II,III,IV	0.511	1.000	.049	1	view →
GBM	DFS	Median	All	0.427	0.314	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ZNF414–LUAD (DFS)

Open the LUAD breakdown →