ZNF414

Across TCGA patient cohorts, ZNF414 mutation is significantly associated with the RNA expression of many other genes, with 187 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF414-associated genes across cancer lineages are RNY1P7, SPINK6, and MIR3156-3. Each is linked with ZNF414 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF414-to-partner and partner-to-ZNF414 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNY1P7 grouped by ZNF414-low versus ZNF414-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF414→partner) and Y-score (partner→ZNF414) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNY1P7 →	+0.133	+3.879	.007	.009	3	2
SCLC	SPINK6 →	+0.211	+5.189	<.001	.006	3	1
BRCA	MIR3156-3 →	+1.992	+7.731	<.001	.009	3	1
UCEC	SGTA →	+0.459	+3.268	.008	.008	3	1
UCEC	LRRC59 →	+0.606	+3.332	.007	.005	3	1
UCEC	ABHD5 →	+0.685	+3.343	.006	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 187 associations by consensus.

RNY1P7 by ZNF414 expression — UCEC

Explore this box plot interactively →