ZNF414

Across TCGA cell cohorts, ZNF414 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,739 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ZNF414-associated GO terms across cancer lineages are Regulation of protein localization to chromatin, Negative regulation of protein localization to chromatin, and Positive regulation of anaphase-promoting complex-dependent catabolic process. Each is linked with ZNF414 in more than 14 cancer types. Because this analysis shows association rather than direction, both ZNF414-to-partner and partner-to-ZNF414 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein localization to chromatin grouped by ZNF414-low versus ZNF414-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF414→partner) and Y-score (partner→ZNF414) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of protein localization to chromatin →	+0.139	+0.917	.001	<.001	3	15
LUNG_NSCLC_LUSC	Negative regulation of protein localization to chromatin →	+0.183	+0.979	<.001	<.001	3	14
BONE	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.163	+0.801	.007	<.001	3	13
BONE	Regulation of glucose mediated signaling pathway →	+0.113	+0.691	.003	.001	3	12
BONE	Positive regulation of glucose mediated signaling pathway →	+0.113	+0.691	.003	.001	3	12
SKIN	Energy coupled proton transmembrane transport, against electrochemical gradient →	+0.086	+0.541	<.001	.005	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,739 associations by consensus.

Regulation of protein localization to chromatin by ZNF414 expression — LUNG_NSCLC_LUSC

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