ZNF414

Across TCGA cell cohorts, ZNF414 mutation is significantly associated with the drug of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF414-associated genes across cancer lineages are Sabutoclax, kb NB 142-70, and LCL161. Each is linked with ZNF414 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF414-to-partner and partner-to-ZNF414 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Sabutoclax grouped by ZNF414-low versus ZNF414-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF414→partner) and Y-score (partner→ZNF414) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Sabutoclax →	+0.485	+2.769	.021	.040	3	1
LARGE_INTESTINE	kb NB 142-70 →	+0.551	+2.652	.019	.045	2	1
LARGE_INTESTINE	LCL161 →	+0.484	+2.646	.002	.047	1	1
LARGE_INTESTINE	ULK1_4989 →	+0.796	+2.649	.015	.046	1	1
LARGE_INTESTINE	WZ3105 →	+0.698	+2.652	.044	.045	1	1
LARGE_INTESTINE	CP724714 →	+0.370	+2.652	.027	.045	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Sabutoclax by ZNF414 expression — LARGE_INTESTINE

Explore this box plot interactively →