ZNF404

Across TCGA pan-cancer cohorts, ZNF404 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ZNF404 data layer compared with 26 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ZNF404 Mutation is associated with better overall survival. In most high-consensus cancer types, elevated ZNF404 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, BLCA, and LUSC are the cancer types where ZNF404 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	II,III,IV	1.000	0.322	.015	22	view →
BLCA	OS	Median	III,IV	0.141	0.581	.011	12	view →
LUSC	OS	Median	All	0.173	0.724	.012	9	view →
LUAD	DFS	Median	All	0.414	0.792	.006	8	view →
SKCM	OS	Median	III,IV	0.245	0.721	.018	5	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ZNF404–UCEC (OS)

Open the UCEC breakdown →