ZNF394

Across TCGA cell cohorts, ZNF394 mutation is significantly associated with the RNA expression of many other genes, with 58 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF394-associated genes across cancer lineages are MRGPRX1, EDDM3A, and ODF4. Each is linked with ZNF394 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF394-to-partner and partner-to-ZNF394 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRGPRX1 grouped by ZNF394-low versus ZNF394-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF394→partner) and Y-score (partner→ZNF394) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MRGPRX1 →	+0.136	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	EDDM3A →	+0.060	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	ODF4 →	+0.046	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	OR6C75 →	+0.043	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	ACCSL →	+0.013	+4.643	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

MRGPRX1 by ZNF394 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →