ZNF391

Across TCGA pan-cancer cohorts, ZNF391 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ZNF391 data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher ZNF391 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZNF391 expression acts as an unfavorable survival marker.

PDAC, LSCC, and HNSC are the cancer types where ZNF391 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.466	0.984	.014	15	view →
LSCC	DFS	Quartile	All	0.440	0.850	.038	6	view →
HNSC	DFS	Tertile	III,IV	0.340	0.811	.028	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ZNF391–PDAC (DFS)

Open the PDAC breakdown →