ZNF391

Across TCGA pan-cancer cohorts, ZNF391 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ZNF391’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where ZNF391 RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF391 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, HNSC, and THCA are the cancer types where ZNF391 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF391 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−1.202	<.001	10	view →
HNSC	All	All	+0.408	.001	9	view →
THCA	Male	II,III,IV	−0.972	<.001	8	view →
BRCA	All	III,IV	−0.934	<.001	6	view →
LUSC	Male	II,III,IV	+0.521	.001	4	view →
COAD	All	All	+0.444	<.001	4	view →
LIHC	All	All	+0.250	.003	3	view →
CHOL	All	All	+1.513	.001	2	view →
READ	All	III,IV	+1.250	.021	2	view →
BLCA	All	All	+0.716	.017	2	view →
PAAD	Female	All	−0.689	.049	2	view →
LUAD	All	All	+0.350	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ZNF391–KICH

Open the KICH breakdown →