ZNF391

Across TCGA patient cohorts, ZNF391 mutation is significantly associated with the RNA expression of many other genes, with 4,903 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF391-associated genes across cancer lineages are CCT7, RPP30, and FAM204A. Each is linked with ZNF391 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF391-to-partner and partner-to-ZNF391 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCT7 grouped by ZNF391-low versus ZNF391-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF391→partner) and Y-score (partner→ZNF391) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCT7 →	+0.489	+2.828	<.001	<.001	3	3
SKCM	RPP30 →	+0.492	+2.855	<.001	.001	3	3
SKCM	FAM204A →	+0.523	+2.459	<.001	.001	3	3
SKCM	NPM3 →	+0.594	+2.446	<.001	.001	3	3
HNSC	RNA5SP86 →	+0.303	+4.912	<.001	.005	3	2
BRCA	RNU6-129P →	+0.588	+8.471	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,903 associations by consensus.

CCT7 by ZNF391 expression — UCEC

Explore this box plot interactively →