ZNF391

Across TCGA patient cohorts, ZNF391 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF391-associated genes across cancer lineages are eEF2, MEK1, and p27_pT198. Each is linked with ZNF391 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF391-to-partner and partner-to-ZNF391 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by ZNF391-low versus ZNF391-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF391→partner) and Y-score (partner→ZNF391) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.310	+3.321	.027	.009	3	3
UCEC	MEK1 →	+0.460	+3.169	.001	<.001	3	2
UCEC	p27_pT198 →	+0.083	+2.321	.047	.034	3	2
UCEC	PCNA →	+0.296	+3.807	<.001	<.001	3	2
UCEC	STAT3_pY705 →	-0.456	-1.807	<.001	.024	3	2
UCEC	ATM →	-0.670	-2.502	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

eEF2 by ZNF391 expression — UCEC

Explore this box plot interactively →