ZNF391

Across TCGA cell cohorts, ZNF391 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF391-associated genes across cancer lineages are CHRNB3, MYF5, and MYOD1. Each is linked with ZNF391 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF391-to-partner and partner-to-ZNF391 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHRNB3 grouped by ZNF391-low versus ZNF391-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF391→partner) and Y-score (partner→ZNF391) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CHRNB3 →	+0.011	+4.467	<.001	.004	3	1
BLOOD_Leukemia	MYF5 →	+0.006	+5.201	.003	.006	3	1
BLOOD_Leukemia	MYOD1 →	+0.015	+4.922	.001	.009	3	1
BLOOD_Leukemia	SPRR1A →	+0.232	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

CHRNB3 by ZNF391 expression — SKIN

Explore this box plot interactively →