ZNF385A

Across TCGA patient cohorts, ZNF385A mutation is significantly associated with the RNA expression of many other genes, with 791 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF385A-associated genes across cancer lineages are HIRIP3, CHAF1B, and FEN1. Each is linked with ZNF385A in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF385A-to-partner and partner-to-ZNF385A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HIRIP3 grouped by ZNF385A-low versus ZNF385A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF385A→partner) and Y-score (partner→ZNF385A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HIRIP3 →	+0.470	+3.732	.001	<.001	3	2
UCEC	CHAF1B →	+0.579	+2.338	.001	.003	3	2
UCEC	FEN1 →	+0.633	+2.415	.001	.003	3	2
UCEC	NIPA1 →	+0.629	+1.869	.002	.005	3	2
UCEC	DEFB104B →	+0.039	+3.668	<.001	.009	3	2
UCEC	ITGAE →	+0.415	+2.928	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 791 associations by consensus.

HIRIP3 by ZNF385A expression — UCEC

Explore this box plot interactively →