ZNF384

Across TCGA cell cohorts, ZNF384 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF384-associated genes across cancer lineages are SH3GL2, DMP1, and FANCD2OS. Each is linked with ZNF384 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF384-to-partner and partner-to-ZNF384 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SH3GL2 grouped by ZNF384-low versus ZNF384-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF384→partner) and Y-score (partner→ZNF384) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SH3GL2 →	+1.558	+3.252	<.001	.009	3	1
LARGE_INTESTINE	DMP1 →	+0.036	+3.743	.002	.001	3	1
LARGE_INTESTINE	FANCD2OS →	+0.102	+3.667	.006	.003	3	1
LARGE_INTESTINE	ETNPPL →	+0.196	+3.938	.002	<.001	3	1
LARGE_INTESTINE	TMCO5A →	+0.015	+3.678	<.001	.001	3	1
LARGE_INTESTINE	OR10W1 →	+0.012	+3.240	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

SH3GL2 by ZNF384 expression — LARGE_INTESTINE

Explore this box plot interactively →