ZNF384

Across TCGA pan-cancer cohorts, ZNF384 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated ZNF384 data layer compared with 5 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher ZNF384 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated ZNF384 expression acts as an unfavorable survival marker, although some lineages such as SCLC and KIRC show a favorable association.

SCLC, KIRC, and HNSC are the cancer types where ZNF384 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	DFS	Median	II,III,IV	0.767	0.413	<.001	54	view →
KIRC	DFS	Tertile	All	0.794	0.506	<.001	54	view →
HNSC	DFS	Quartile	All	0.770	0.591	.002	53	view →
COAD	DFS	Quartile	All	0.520	0.745	.001	48	view →
ACC	DFS	Median	All	0.531	0.782	<.001	35	view →
UCEC	DFS	Median	IV	0.670	0.276	.011	30	view →
PAAD	OS	Median	All	0.497	0.770	<.001	24	view →
OV	OS	Quartile	III,IV	0.273	0.415	.004	24	view →
LUAD	DFS	Median	All	0.742	0.836	.002	24	view →
KIRP	OS	Median	II,III,IV	0.459	0.932	.002	22	view →
LIHC	DFS	Quartile	All	0.451	0.608	.009	19	view →
UCS	DFS	Tertile	IV	0.956	0.381	.024	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

ZNF384–SCLC (DFS)

Open the SCLC breakdown →