ZNF366

Across TCGA cell cohorts, ZNF366 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible ZNF366-associated genes across cancer lineages are RESP18, SI, and CDX4. Each is linked with ZNF366 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF366-to-partner and partner-to-ZNF366 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RESP18 grouped by ZNF366-low versus ZNF366-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF366→partner) and Y-score (partner→ZNF366) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	RESP18 →	+0.021	+3.362	<.001	.007	3	2
BLOOD_Lymphoma	SI →	+0.013	+4.058	<.001	.009	3	2
CNS	CDX4 →	+0.013	+6.357	<.001	<.001	3	1
CNS	C10orf71 →	+0.016	+4.981	<.001	.008	3	1
SKIN	DYDC1 →	+0.096	+3.684	<.001	.006	3	1
SKIN	OR5B2 →	+0.038	+3.920	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

RESP18 by ZNF366 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →