ZNF354C

Across TCGA pan-cancer cohorts, ZNF354C Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ZNF354C data layer compared with 26 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ZNF354C Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated ZNF354C expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, HNSC, and SCLC are the cancer types where ZNF354C Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.970	0.615	.004	28	view →
HNSC	OS	Median	II,III,IV	0.167	0.761	<.001	26	view →
SCLC	DFS	Median	II,III,IV	0.137	0.602	.008	18	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ZNF354C–UCEC (DFS)

Open the UCEC breakdown →