ZNF354C

Across TCGA pan-cancer cohorts, ZNF354C RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of ZNF354C’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ZNF354C RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF354C is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and UCEC are the cancer types where ZNF354C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF354C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	II,III,IV	−0.987	<.001	10	view →
KICH	Male	All	−1.520	<.001	8	view →
UCEC	All	All	−1.203	<.001	6	view →
BRCA	All	III,IV	−0.700	<.001	6	view →
COAD	Female	All	−0.501	.001	4	view →
LUAD	Female	II,III,IV	−0.444	.040	3	view →
CHOL	All	All	+0.969	<.001	2	view →
READ	All	All	−0.867	.018	2	view →
STAD	All	All	−0.453	.024	1	view →
LUSC	Male	All	−0.339	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

ZNF354C–THCA

Open the THCA breakdown →