ZNF354C

Across TCGA patient cohorts, ZNF354C mutation is significantly associated with the RNA expression of many other genes, with 3,865 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF354C-associated genes across cancer lineages are R3HCC1L, MORN4, and CDPF1. Each is linked with ZNF354C in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF354C-to-partner and partner-to-ZNF354C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, R3HCC1L grouped by ZNF354C-low versus ZNF354C-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF354C→partner) and Y-score (partner→ZNF354C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	R3HCC1L →	+0.593	+2.241	.007	.006	3	2
SKCM	MORN4 →	+0.555	+3.347	.003	.004	3	2
SKCM	CDPF1 →	+0.360	+2.613	.006	.005	3	2
SKCM	LINC01821 →	+0.020	+2.227	.002	.008	3	2
UCEC	CRYBB2P1 →	+0.457	+2.343	<.001	<.001	3	2
UCEC	LMF2 →	+0.410	+3.980	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,865 associations by consensus.

R3HCC1L by ZNF354C expression — SKCM

Explore this box plot interactively →