ZNF354C

Across TCGA patient cohorts, ZNF354C mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF354C-associated genes across cancer lineages are ATM, 4E-BP1_pT37_T46, and NF2. Each is linked with ZNF354C in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF354C-to-partner and partner-to-ZNF354C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ZNF354C-low versus ZNF354C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF354C→partner) and Y-score (partner→ZNF354C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.464	-1.523	.001	.008	3	4
UCEC	4E-BP1_pT37_T46 →	-0.238	-1.687	.047	.040	3	3
COAD	NF2 →	+0.199	+2.178	.029	.035	3	3
COAD	EGFR_pY1068 →	-0.481	-3.313	.001	.010	3	2
UCEC	JNK_pT183_Y185 →	-0.172	-2.169	.001	.003	3	2
UCEC	JNK2 →	+0.223	+2.424	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

ATM by ZNF354C expression — UCEC

Explore this box plot interactively →