ZNF35

Across TCGA patient cohorts, ZNF35 mutation is significantly associated with the RNA expression of many other genes, with 1,699 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF35-associated genes across cancer lineages are PSMD6, LSM3, and SPATA5L1. Each is linked with ZNF35 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF35-to-partner and partner-to-ZNF35 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMD6 grouped by ZNF35-low versus ZNF35-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF35→partner) and Y-score (partner→ZNF35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	PSMD6 →	+0.448	+3.203	<.001	.009	3	3
UCEC	LSM3 →	+0.671	+3.743	<.001	<.001	3	3
UCEC	SPATA5L1 →	+0.418	+2.332	.003	<.001	3	3
UCEC	ZWILCH →	+0.569	+2.431	<.001	.001	3	3
UCEC	PDE12 →	+0.524	+3.818	<.001	<.001	3	3
UCEC	MCOLN1 →	+0.462	+3.818	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,699 associations by consensus.

PSMD6 by ZNF35 expression — STAD

Explore this box plot interactively →