ZNF35

Across TCGA pan-cancer cohorts, ZNF35 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ZNF35’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ZNF35 RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF35 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, HNSC, and STAD are the cancer types where ZNF35 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF35 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.662	<.001	8	view →
HNSC	All	IV	+0.407	.008	8	view →
STAD	All	II,III,IV	+0.632	<.001	7	view →
UCEC	All	II,III,IV	+0.904	<.001	6	view →
LIHC	Female	II,III,IV	+0.846	<.001	6	view →
COAD	All	All	+0.429	<.001	6	view →
KICH	All	All	−0.698	<.001	5	view →
KIRC	All	II,III,IV	−0.261	.001	5	view →
BRCA	All	All	+0.268	<.001	4	view →
CHOL	Male	All	+1.634	<.001	3	view →
READ	Male	All	+0.543	.028	2	view →
BLCA	All	IV	+0.312	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ZNF35–THCA

Open the THCA breakdown →