ZNF346-IT1

Across TCGA pan-cancer cohorts, ZNF346-IT1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated ZNF346-IT1 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher ZNF346-IT1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZNF346-IT1 expression acts as an unfavorable survival marker, although some lineages such as UCS and PAAD show a favorable association.

UVM, UCS, and THCA are the cancer types where ZNF346-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	III,IV	0.095	1.000	.001	47	view →
UCS	OS	Tertile	IV	0.781	0.206	.024	36	view →
THCA	OS	Quartile	II,III,IV	0.875	0.975	.008	35	view →
UCEC	DFS	Quartile	All	0.494	0.651	.015	30	view →
PAAD	OS	Quartile	All	0.606	0.276	.003	24	view →
CHOL	DFS	Quartile	II,III,IV	0.120	0.741	.024	19	view →
LIHC	DFS	Tertile	All	0.429	0.620	.001	18	view →
BRCA	OS	Tertile	III,IV	0.944	0.846	.007	14	view →
MESO	DFS	Quartile	III,IV	0.212	0.668	.010	12	view →
ACC	DFS	Median	IV	0.123	0.563	<.001	12	view →
STAD	OS	Tertile	III,IV	0.555	0.762	.011	11	view →
LUSC	DFS	Quartile	III,IV	0.405	1.000	.008	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

ZNF346-IT1–UVM (DFS)

Open the UVM breakdown →