ZNF346-IT1

Across TCGA pan-cancer cohorts, ZNF346-IT1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of ZNF346-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ZNF346-IT1 RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF346-IT1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, LIHC, and COAD are the cancer types where ZNF346-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF346-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−0.518	<.001	8	view →
LIHC	All	II,III,IV	+0.232	<.001	7	view →
COAD	All	II,III,IV	+0.319	<.001	6	view →
CHOL	All	All	+0.952	<.001	5	view →
KICH	All	All	−0.291	.002	3	view →
KIRC	Female	IV	−0.296	.033	1	view →
LUAD	All	All	+0.242	.040	1	view →
HNSC	Male	IV	+0.202	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

ZNF346-IT1–THCA

Open the THCA breakdown →