ZNF343

Across TCGA patient cohorts, ZNF343 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF343-associated genes across cancer lineages are Notch1, PCNA, and Rictor_pT1135. Each is linked with ZNF343 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF343-to-partner and partner-to-ZNF343 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by ZNF343-low versus ZNF343-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF343→partner) and Y-score (partner→ZNF343) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.205	+3.598	<.001	.001	3	2
UCEC	PCNA →	+0.259	+2.700	.002	.006	3	2
UCEC	Rictor_pT1135 →	-0.081	-1.584	.042	.036	3	2
UCEC	Caspase-8 →	-0.262	-2.558	.008	.010	3	2
UCEC	Cyclin-B1 →	+0.700	+2.502	.001	.002	3	2
SKCM	YAP →	+0.241	+2.820	.019	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Notch1 by ZNF343 expression — UCEC

Explore this box plot interactively →