ZNF337

Across TCGA patient cohorts, ZNF337 mutation is significantly associated with the RNA expression of many other genes, with 3,091 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF337-associated genes across cancer lineages are L3MBTL2, TRMU, and CEP76. Each is linked with ZNF337 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF337-to-partner and partner-to-ZNF337 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, L3MBTL2 grouped by ZNF337-low versus ZNF337-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF337→partner) and Y-score (partner→ZNF337) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	L3MBTL2 →	+0.404	+1.847	<.001	<.001	3	2
UCEC	TRMU →	+0.537	+3.424	<.001	<.001	3	2
UCEC	CEP76 →	+0.397	+2.928	<.001	<.001	3	2
UCEC	GPR143 →	-0.711	-2.422	<.001	<.001	3	2
UCEC	PHF7 →	+0.358	+2.467	.002	.001	3	2
UCEC	ZNF200 →	+0.305	+1.888	.002	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,091 associations by consensus.

L3MBTL2 by ZNF337 expression — UCEC

Explore this box plot interactively →