Across TCGA pan-cancer cohorts, ZNF32-AS3 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of ZNF32-AS3’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where ZNF32-AS3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZNF32-AS3 is over-expressed in tumor, although a few such as LUAD show the opposite, repressed pattern.
COAD, LUAD, and CHOL are the cancer types where ZNF32-AS3 tumor–normal differential expression is most reproducible.